 |
|
Tuberculosis
Multidrug-resistant tuberculosis (MDR-TB) is defined as tuberculosis that is resistant to the most powerful first-line treatment of two and isoniazid (INH) rifampicin (RMP), for tuberculosis at least. Resistant, but not a combination of any of several other agents for INH RMP tuberculosis isolates is not classified as MDR-TB. The MDR-TB, course of antibiotics is interrupted, drug concentration in the body, is not sufficient to kill 100% of bacteria, but it has developed into treatable TB that it is not so. Sometimes may stop the course of the antibiotic and feel good, the supply of drugs is insufficient, or to become a shortage of patients can occur for several reasons, this is, at any time the patient to obtain effective treatment there is forget or you will take the medicine to the patient. TB treatment Most are composed of chemotherapy treatment of short-term course is a small percentage of patients with multidrug-resistant tuberculosis. MDR TB delay of second-line drugs is to treat difficult. MDR-TB is spread from person to person as easily in the same way as drug-sensitive tuberculosis. But, still high from the patent medicine of anti-TB price of the second line, it is a major problem for patients living in poor countries to be treated. In untreated patients, the incidence of tuberculosis is a problem in poor countries. To cure infectious diseases such as tuberculosis completely, we plan to ensure equal access to medical care is required.
Epidemiology
Case MDR TB were reported in each study. In most cases, it is carried out in the course of tuberculosis treatment, MDR-TB, because a failure to complete the treatment or patient dose or physician, provides a therapeutic inappropriate most often is missing is. Because it is a MDR tuberculosis, human pathogen in the air and active pulmonary tuberculosis will be able to send the sick caused by multi-drug resistant strains if they cough and alive. In many cases, tuberculosis strain is a little less infectious, (for example with HIV patients) to people with, generation occurs more easily weakened immune system. Epidemic meet among healthy people of non-immune dysfunction, but it is rare. As of 2013, 3.7% of new TB cases are MDR-TB. About 20% - level is much higher in patients treated for tuberculosis. WHO estimates that there are cases of MDR-TB in new 0.5 million people worldwide in 2011. Approximately 60% of these cases that have occurred in China, Brazil, India, Russia, South Africa alone.In Moldova collapsed health system has led to the rise of MDR-TB. Number of cases is still small, but in 2013, the border of Mexico and the United States "is a very hot area of drug-resistant tuberculosis" It should be noted that it was. This is, that for many years, is a pathogenic much in epidemiological data INH resistant tuberculosis and guinea pigs, are known, MDR-TB strain is not naturally control. In a study in Los Angeles, California, found that only 6% of MDR-TB cases were clustered. In addition, the appearance of the high level of MDR-TB is associated with an explosion of AIDS in the art in New York in 1990 early. In New York City, said to be capable of 80% full of MDR-TB cases of all dating back to the homeless shelter or prison is the report that was issued by the health authorities of the city. The MDR-TB patients, about two years of a plurality of circuits, they need a long treatment period. Some of the less powerful drugs, and is also toxic side effects nausea, abdominal pain, and further such as psychosis the second line is necessary for the treatment of MDR-TB. I had to treat patients of Peru who was suffering from a strain that is resistant to the drug 10 or 12 also a partner of the medical team. Most of these patients require salvage surgery to the desired one of the treatment.
Clinical Manifestations
The XDR-TB patients with MDR-TB, I present with clinical symptoms as well as patients with strains of traditional tuberculosis. Night sweats, fever, chills, weight loss, cough, hemoptysis, and chest pain: clinical symptoms of pulmonary tuberculosis, may include some or all of the following. TB affects the respiratory system primarily, but it also is kidney, meninges, bones, joints, can and will affect the other parts of the body such as the abdominal muscles. Therefore, clinical features other is dependent on the part of the body affected by the bacteria Mycobacterium tuberculosis be present in tuberculosis patients, and can be. While it is treatable generally, according to the World Health Organization ", it is more expensive drugs first line more, TB is intensive and second line drugs for TB to be treated results in that certain side effects more severe, but it is easy to treat (up to 2 years of treatment) chemotherapy is required. "
GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45 Fax 0032 16 50 90 45 info@gentaur.com GENTAUR Ltd. GB111298832 Howard Frank Turnberry House 1404-1410 High Road Whetstone London N20 9BH Tel 020 3393 8531 Fax 020 8445 9411 |
GENTAUR France SARL FR63484237888 9, rue Lagrange, 75005 Paris Tel 01 43 25 01 50 Fax 01 43 25 01 60 RCS Paris B 484 237 888 SIRET 48423788800017 RIB 30004 00187 00010092253 10 BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG IBAN FR76 3000 4001 8700 0100 9225 310 france@gentaur.com |
GENTAUR GmbH DE815175831 Marienbongard 20 52062 Aachen Deutschland de@gentaur.com Tel 0241 95 78 94 78 Tacka Vancheva Tel logistics 0241 4008 9086 Annick Verdeyen Fax 0241 55 91 05 36 Bankleitzahl 39050000 IBAN DE8839050000107569353 Handelsregister Aachen HRB16058 Steuernummer 201/5961/3925 de@gentaur.com |
GENTAUR Nederland BV NL850396268B01 Kuiper 1 5521 DG Eersel Nederland KVK nummer 52327027 Tel: 0208-080893 Fax: 0497-517897 nl@gentaur.com IBAN: NL04RABO0156985462 SWIFT RABONL2U GENTAUR Ltd. GB111298832 Howard Frank Turnberry House 1404-1410 High Road Whetstone London N20 9BH Tel 020 3393 8531 Fax 020 8445 9411 |
GENTAUR U.S.A Genprice Inc, Logistics 547, Yurok Circle San Jose, CA 95123 Phone: (408) 472-2934 Fax:(408) 416-3994 Phone (718)513-2983 sales@genprice.com Genprice Inc, Invoices and accounting 6017 Snell Ave San Jose, CA 95123 |
GENTAUR Italy 20135 Milano Tel 0236006593 Fax 0350085071 italia@gentaur.com GENTAUR Spain tel:0911876558 spain@gentaur.com GENTAUR BULGARIA BG20135893153, Graf Ignatiev Str. ent.V, fl. 2 Sofia 1000 Tel 0035929830070 Fax 0035929830072 sofia@gentaur.com |
ГЕНТАУЪР БЪЛГАРИЯ ID # 201 358 931 BULSTAT София 1000 ул. "Граф Игнатиев" 53 вх. В, ет. 2 Tel 0035929830070 Fax 0035929830072 e-mail: Sofia@gentaur.com IBAN: BG11FINV91501014771636 BIC: FINVBGSF |
Other countries Österreich +43720880899 Canada Montreal +15149077481 Ceská republika Praha +420246019719 Danmark +4569918806 Finland Helsset +358942419041 Magyarország Budapest +3619980547 Ireland Dublin +35316526556 Luxembourg +35220880274 Norge Oslo +4721031366 Sverige Stockholm +46852503438 Schweiz Züri +41435006251 US New York +17185132983 |