Psalmotoxin 1 - PcTx1

Psalmotoxin 1: Toxin properties

Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). This toxin is known to block potently (IC50 = 1 nM) and selectively the H+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible. The toxin can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. Psalmotoxin 1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.

Product Specification

AA sequence: Glu-Asp-Cys3-Ile-Pro-Lys-Trp-Lys-Gly-Cys10-Val-Asn-Arg-His-Gly-Asp-Cys17-Cys18-Glu-Gly-Leu-Glu-Cys23-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys33-Val-Pro-Lys-Thr-Pro-Lys-Thr
(Disulfide bonds between Cys3-Cys18, Cys10-Cys23 and Cys17-Cys33)
Length (aa): 40
Formula: C200H312N62O57S6
Molecular Weight: 4690.82 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic 
Purity rate: > 98%

Price & Quantities

Other quantities available upon request