Hainantoxin-IV

Toxin properties

Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spider Ornithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). It binds to TTX-S with an IC50value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by hainantoxin IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.

Product specifications

AA sequence: Glu-Cys2-Leu-Gly-Phe-Gly-Lys-Gly-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16-Cys17-Lys-Ser-Ser-Asn-Leu-Val-Cys24-Ser-Arg-Lys-His-Arg-Trp-Cys31-Lys-Tyr-Glu-Ile-NH2 
(Disulfide bonds between Cys2-Cys17, Cys9-Cys24, and Cys16-Cys31) 
Length (aa): 35 
Formula: C166H257N53O50S6 
Molecular Weight: 3987.6 Da 
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: Not available
Source: Synthetic 
Purity rate: > 97%

Prices & Quantities

Reference #	Prodcut name	Quantity (mg)
12HTX001-00100	Hainantoxin IV	0.1
12HTX001-00500	Hainantoxin IV	0.5
12HTX001-01000	Hainantoxin IV	1

Other quantities available upon request