GaTx2

GaTx2: Toxin Properties

GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx2 is the most potent peptide inhibitor of ClC-2 chloride channel ever described. Kd value is close to 20 pM. GaTx2 slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally, GaTx2 is composed of two β-strands and one α-helix. This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.

Product Specifications

AA sequence: H-Val-Ser-Cys3-Glu-Asp-Cys6-Pro-Asp-His-Cys10-Ser-Thr-Gln-Lys-Ala-Arg-Ala-Lys-Cys19-Asp-Asn-Asp-Lys-Cys24-Val-Cys26-Glu-Pro-Ile-OH
(Disulfide bonds between Cys3-Cys19, Cys6-Cys24, and Cys10-Cys26)
Length (aa): 29
Formula: C125H199N39O47S6
Molecular Weight: 3191.25 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic

Price & Quantities

Reference #	Product name	Quantity (mg)
10GTX002-00100	GaTx2	0.1
10GTX002-00500	GaTx2	0.5
10GTX002-01000	GaTx2	1

Other quantities available upon request