Gentaur's Products: Innovative and High Quality Peptide Toxins
Protoxin II (ProTx II)
Protoxin II: toxin properties
Protoxin II (ProTx II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant channels. This toxin inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. The toxin potently inhibits all sodium channel subtypes tested (Nav1.2/SCN2A, Nav1.5/SCN5A, Nav1.7/SCN9A, and Nav1.8/SCN10A). It is approximately 15-fold more potent on Nav1.7/SCN9A than on Nav1.5/SCN5A channels and acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. Protoxin II also binds to phospholipids. ProTx-II, a selective inhibitor of Nav1.7 sodium channels, blocks action potential propagation in nociceptors.
Product Specification
AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
(Disulfide bonds between Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25)
Length (aa): 30
Formula: C168H250N46O41S8
Molecular Weight: 3828.00 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 484598-36-9
Source: Synthetic
Purity rate: > 95 %
Price & Quantities
| Reference # | Product name | Quantity (mg) |
| 07PTX002-00100 | ProTx II | 0.1 |
| 07PTX002-00500 | ProTx II | 0.5 |
| 07PTX002-01000 | ProTx II | 1 |
