Gentaur's Products: Innovative and High Quality Peptide Toxins
Tertiapin Q: toxin properties
Tertiapin has been isolated from the venom of the Honeybee Apis mellifera (African tarantula) tertiapin-Q is a mutant of tertiapin where M13 has been mutated by Q in order to increase your stability. This is a neurotoxin with presynaptic activity that blocks the inwardly rectifying Kir1.1 (KCNJ1) and Kir3.1/3.4 (KCNJ3/KCNJ5) potassium channels with high affinity by binding to the M1-M2 linker region of these channels in a 1:1 stoichiometry. Tertiapin-Q also inhibits calcium-activated large conductance BK-type (KCNMA/KCNMB) potassium channels in a concentration, and voltage-dependent manner, in addition to inhibiting Kir3.1/3.2 (KCNJ3/KCNJ6) heteromultimer potassium channels. It can prevent dose-dependent acetylcholine(ACh)-induced atrioventricular blocks in mammalian hearts, as KCNJ3/KCNJ5 channels (also named I(KACh)), are activated by ACh found in mammalian myocytes. This toxin interacts specifically with calmodulin in the presence of calcium.
Product Specifications
AA sequence: H-Ala-Leu-Cys3-Asn-Cys5-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys14-Trp-Lys-Lys-Cys18-Gly-Lys-Lys-NH2
(Disulfide bonds between Cys3-Cys14 and Cys5-Cys18)
Length (aa): 21
Formula: C106H175N35O24S4
Molecular Weight: 2452 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [252198-49-5]
Source: Synthetic
Purity rate: > 97 %
Price & Quantities
| Reference # | Product name | Quantity (mg) |
| 08TER001-00100 | Tertiapin Q | 0.1 |
| 08TER001-00500 | Tertiapin Q | 0.5 |
| 08TER001-01000 | Tertiapin Q | 1 |
Other quantities available upon request
