Huwentoxin IV

Huwentoxin IV: toxin properties

Huwentoxin IV is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC50 of 30 nM in rat DRG neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNav1.7 (SCN9A) (IC50 is 26 nM), rNav1.2 (SCN2A) (IC50 is 150 nM), and rNav1.3 (SCN3A) (IC50 is 338 nM), compared with muscle subtypes rNav1.4 (SCN4A) and hNav1.5 (SCN5A) (IC50 is > 10 µM). Huwentoxin IV inhibits the activation of sodium channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.

Product Specification

AA sequence: H-Glu-Cys2-Leu-Glu-Ile-Phe-Lys-Ala-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16-Cys17-Lys-Ser-Ser-Lys-Leu-Val-Cys24-Ser-Arg-Lys-Thr-Arg-Trp-Cys31-Lys-Tyr-Gln-Ile-NH2
(Disulfide bonds between Cys2-Cys17, Cys9-Cys24 and Cys16-Cys31)
Length (aa): 35
Formula: C174H277N51O52S6
Molecular Weight: 4109.18 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic 
Purity rate: > 97 %

Price & quantities

Other quantities available upon request