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| Blood Urea Nitrogen (BUN), Kinetic, 20 x 12 ml | |
| Product | Blood Urea Nitrogen (BUN), Kinetic, 20 x 12 ml |
|---|---|
| Catalog Number | BQ009C-CR |
| Quantity | 240 Tests |
| Sample Type | Serum or from hemolysis |
| Description | Urea is the major end product of protein nitrogen metabolism. It is synthesized in the liver from ammonia, which is produced by amino acid deamination. The determination of serum urea nitrogen is an important index of kidney function. Impaired renal function or increased tissue protein breakdown are associated with increased urea nitrogen levels, whereas liver damage or pregnancy are associated with decreased levels. Urea in the sample is hydrolyzed by urease to produce ammonia and carbon dioxide. The liberated ammonia reacts with 2-oxoglutarate, in the presence of GD and the coenzyme NADH, to produce L-glutamate. In this reaction 2 moles of NADH are oxidized to NAD for each mole of urea hydrolyzed. The resulting decrease in absorbance of NADH at 340 nm is proportional to the level of urea nitrogen in the sample. |
| Species | Human |
