Apoptosis

Apoptosis is a process of deliberate suicide by a cell in a multi-cellular organism. It is one of the main types of programmed cell death, and involves an orchestrated series of biochemical events leading to a characteristic cell morphology and death. The apoptotic process is executed in such a way as to safely dispose of cell corpses and fragments.

Apoptosis can occur when a cell is damaged beyond repair, infected with a virus, or undergoing stress conditions such as starvation. The tumor-suppressing gene p53 can also induce apoptosis via DNA damage or toxic chemicals.

The decision for apoptosis can come from the cell itself, from the surrounding tissue, or from a cell that is part of the immune system. Because of this connection with the immune system, apoptosis is studied in an extensive variety of diseases including HIV and cancer.

Product	Category	Clone #	Catalog #	Size	Description	Research Area
Aclacinomycin A	Small Molecules	N/A	SIH-335-5MG	5mg	Proteasome inhibitor	Apoptosis
Actinomycin D	Small Molecules	N/A	SIH-245-10MG	10mg	Transcription inhibitor	Apoptosis
Actinomycin D	Small Molecules	N/A	SIH-245-50MG	50mg	Transcription inhibitor	Apoptosis
Amifostine	Small Molecules	N/A	SIH-210-10MG	10mg	Cellular protectant	Apoptosis
Amifostine	Small Molecules	N/A	SIH-210-50MG	50mg	Cellular protectant	Apoptosis
Andrographolide	Small Molecules	N/A	SIH-220-100MG	100mg	Induces mitochondrial -mediated apoptosis in lymphoma cells	Apoptosis
Andrographolide	Small Molecules	N/A	SIH-220-500MG	500mg	Induces mitochondrial -mediated apoptosis in lymphoma cells	Apoptosis
Anisomycin	Small Molecules	N/A	SIH-266-10MG	10mg	anoikis sensitizer	Apoptosis
Anisomycin	Small Molecules	N/A	SIH-266-50MG	50mg	anoikis sensitizer	Apoptosis
Antibiotic A-23187	Small Molecules	N/A	SIH-227-10MG	10mg	Ca2+ ionophore	Apoptosis
Antibiotic A-23187	Small Molecules	N/A	SIH-227-50MG	50mg	Ca2+ ionophore	Apoptosis
Apigenin	Small Molecules	N/A	SIH-249-10MG	10mg	Protein kinase inhibitor	Apoptosis
Apigenin	Small Molecules	N/A	SIH-249-50MG	50mg	Protein kinase inhibitor	Apoptosis
Betulinic Acid	Small Molecules	N/A	SIH-221-10MG	10mg	Induces mitochondrial permeability pore opening	Apoptosis
Betulinic Acid	Small Molecules	N/A	SIH-221-50MG	50mg	Induces mitochondrial permeability pore opening	Apoptosis
BIM/BOD (IN) Antibody	Antibodies	N/A	SPC-113C	25ug		Apoptosis
BIM/BOD (IN) Antibody	Antibodies	N/A	SPC-113D	100ug		Apoptosis
BIM/BOD (IN2)	Antibodies	N/A	SPC-164C	25ug		Apoptosis
BIM/BOD (IN2) Antibody	Antibodies	N/A	SPC-164D	100ug		Apoptosis
Bortezomib	Small Molecules	N/A	SIH-328-5MG	5mg	Proteasome inhibitor	Apoptosis
Bortezomib	Small Molecules	N/A	SIH-328-25MG	25mg	Proteasome inhibitor	Apoptosis
Brefeldin A	Small Molecules	N/A	SIH-225-10MG	10mg	Inhibits intracellular transport	Apoptosis
Brefeldin A	Small Molecules	N/A	SIH-225-50MG	50mg	Inhibits intracellular transport	Apoptosis
C2 Ceramide	Small Molecules	N/A	SIH-232-10MG	10mg	Cell permeable ceramide analog	Apoptosis
C2 Ceramide	Small Molecules	N/A	SIH-232-50MG	50mg	Cell permeable ceramide analog	Apoptosis
Camptothecin	Small Molecules	N/A	SIH-242-100MG	100mg	Topoisomerase I inhibitor	Apoptosis
Camptothecin	Small Molecules	N/A	SIH-242-1G	1g	Topoisomerase I inhibitor	Apoptosis
CAPE	Small Molecules	N/A	SIH-263-50MG	50mg	Inhibits NFkB activation	Apoptosis
CAPE	Small Molecules	N/A	SIH-263-250MG	250mg	Inhibits NFkB activation	Apoptosis
Celastrol	Small Molecules	N/A	SIH-333-10MG	10mg	Proteasome inhibitor	Apoptosis
Celastrol	Small Molecules	N/A	SIH-333-50MG	50mg	Proteasome inhibitor	Apoptosis
Cycloheximide	Small Molecules	N/A	SIH-247-1G	1g	Translation inhibitor	Apoptosis
Cycloheximide	Small Molecules	N/A	SIH-247-5G	5g	Translation inhibitor	Apoptosis
Cyclopamine	Small Molecules	N/A	SIH-226-1MG	1mg	Inhibits hedgehog signaling	Apoptosis
Cyclopamine	Small Molecules	N/A	SIH-226-5MG	5mg	Inhibits hedgehog signaling	Apoptosis
Cyclosporine	Small Molecules	N/A	SIH-201-10MG	10mg	Inhibits mitochondrial permeability pore opening	Apoptosis
Cyclosporine	Small Molecules	N/A	SIH-201-50MG	50mg	Inhibits mitochondrial permeability pore opening	Apoptosis
Cytochalasin D	Small Molecules	N/A	SIH-241-1MG	1mg	Disrupts actin filaments	Apoptosis
Cytochalasin D	Small Molecules	N/A	SIH-241-5MG	5mg	Disrupts actin filaments	Apoptosis
DBeQ	Small Molecules	N/A	SIH-334-5MG	5mg	p97 Inhibitor	Apoptosis
DBeQ	Small Molecules	N/A	SIH-334-25MG	25mg	p97 Inhibitor	Apoptosis
Deguelin	Small Molecules	N/A	SIH-251-10MG	10mg	Akt inhibitor	Apoptosis
Deguelin	Small Molecules	N/A	SIH-251-50MG	50mg	Akt inhibitor	Apoptosis
Deprenyl	Small Molecules	N/A	SIH-209-100MG	100mg	glyceraldehyde-3-phosphate dehydrogenase inhibitor AND MAO-B Inhibitor	Apoptosis
Deprenyl	Small Molecules	N/A	SIH-209-1G	1g	glyceraldehyde-3-phosphate dehydrogenase inhibitor AND MAO-B Inhibitor	Apoptosis
Dexamethasone	Small Molecules	N/A	SIH-259-1G	1g	Apoptosis inducing glucocorticoid	Apoptosis
Dexamethasone	Small Molecules	N/A	SIH-259-5G	5g	Apoptosis inducing glucocorticoid	Apoptosis
Difluoromethylornithine	Small Molecules	N/A	SIH-200-10MG	10mg	Inhibits polyamine biosynthesis	Apoptosis
Difluoromethylornithine	Small Molecules	N/A	SIH-200-50MG	50mg	Inhibits polyamine biosynthesis	Apoptosis
Docetaxel	Small Molecules	N/A	SIH-240-10MG	10mg	Microtubule stabilizing agent	Apoptosis
Docetaxel	Small Molecules	N/A	SIH-240-50MG	50mg	Microtubule stabilizing agent	Apoptosis
Ebselen	Small Molecules	N/A	SIH-204-10MG	10mg	Glutathione peroxidase mimic	Apoptosis
Ebselen	Small Molecules	N/A	SIH-204-50MG	50mg	Glutathione peroxidase mimic	Apoptosis
Epothilone B	Small Molecules	N/A	SIH-238-1MG	1mg	Microtubule stabilizing agent	Apoptosis
Epothilone B	Small Molecules	N/A	SIH-238-5MG	5mg	Microtubule stabilizing agent	Apoptosis
Etoposide	Small Molecules	N/A	SIH-244-100MG	100mg	Topoisomerase II inhibitor	Apoptosis
Etoposide	Small Molecules	N/A	SIH-244-500MG	500mg	Topoisomerase II inhibitor	Apoptosis
FCCP	Small Molecules	N/A	SIH-222-10MG	10mg	Inhibits mitochondrial oxidative phosphorylation	Apoptosis
FCCP	Small Molecules	N/A	SIH-222-50MG	50mg	Inhibits mitochondrial oxidative phosphorylation	Apoptosis
FK506	Small Molecules	N/A	SIH-214-10MG	10mg	FKBP inhibitor	Apoptosis
FK506	Small Molecules	N/A	SIH-214-50MG	50mg	FKBP inhibitor	Apoptosis
Forskolin	Small Molecules	N/A	SIH-208-10MG	10mg	Adenylate cyclase activator	Apoptosis
Forskolin	Small Molecules	N/A	SIH-208-50MG	50mg	Adenylate cyclase activator	Apoptosis
Fumonisin B1	Small Molecules	N/A	SIH-234-1MG	1mg	Blocks sphingolipid biosynthesis	Apoptosis
Fumonisin B1	Small Molecules	N/A	SIH-234-5MG	5mg	Blocks sphingolipid biosynthesis	Apoptosis
Hypericin	Small Molecules	N/A	SIH-250-1MG	1mg	Protein kinase C inhibitor	Apoptosis
Hypericin	Small Molecules	N/A	SIH-250-10MG	10mg	Protein kinase C inhibitor	Apoptosis
Ionomycin	Small Molecules	N/A	SIH-228-1MG	1mg	Ca2+ ionophore	Apoptosis
Ionomycin	Small Molecules	N/A	SIH-228-5MG	5mg	Ca2+ ionophore	Apoptosis
Irinotecan HCl	Small Molecules	N/A	SIH-243-50MG	50mg	Topoisomerase I inhibitor	Apoptosis
Irinotecan HCl	Small Molecules	N/A	SIH-243-250MG	250mg	Topoisomerase I inhibitor	Apoptosis
IU1	Small Molecules	N/A	SIH-329-10MG	10mg	Usp-14 Inhibitor	Apoptosis
IU1	Small Molecules	N/A	SIH-329-50MG	50mg	Usp-14 Inhibitor	Apoptosis
Lactacystin	Small Molecules	N/A	SIH-327-200ug	200ug	Proteasome inhibitor	Apoptosis
Lactacystin	Small Molecules	N/A	SIH-327-1MG	1mg	Proteasome inhibitor	Apoptosis
LDN-57444	Small Molecules	N/A	SIH-332-10MG	10mg	DUB Inhibitor	Apoptosis
LDN-57444	Small Molecules	N/A	SIH-332-50MG	50mg	DUB Inhibitor	Apoptosis
Lovastatin	Small Molecules	N/A	SIH-256-10MG	10mg	HMG-CoA reductase inhibitor	Apoptosis
Lovastatin	Small Molecules	N/A	SIH-256-50MG	50mg	HMG-CoA reductase inhibitor	Apoptosis
LY 294002 HCl	Small Molecules	N/A	SIH-252-5MG	5mg	PI 3-Kinase inhibitor	Apoptosis
LY 294002 HCl	Small Molecules	N/A	SIH-252-25MG	25mg	PI 3-Kinase inhibitor	Apoptosis
MDBN	Small Molecules	N/A	SIH-342-100MG	100mg	p97 inhibitor	Apoptosis
Mifepristone (RU486)	Small Molecules	N/A	SIH-211-100MG	100mg	Glucocorticoid antagonist	Apoptosis
Mifepristone (RU486)	Small Molecules	N/A	SIH-211-500MG	500mg	Glucocorticoid antagonist	Apoptosis
Mitomycin C	Small Molecules	N/A	SIH-246-10MG	10mg	DNA crosslinking and damaging agent	Apoptosis
Mitomycin C	Small Molecules	N/A	SIH-246-50MG	50mg	DNA crosslinking and damaging agent	Apoptosis
MLN-4924	Small Molecules	N/A	SIH-331-200ug	200ug	Nedd8 activating enz inhibitor	Apoptosis
MLN-4924	Small Molecules	N/A	SIH-331-1MG	1mg	Nedd8 activating enz inhibitor	Apoptosis
MMP9 Antibody	Antibodies	S51-82	SMC-396D	100ug		Apoptosis, Neuroscience
Myriocin (ISP-1)	Small Molecules	N/A	SIH-233-5MG	5mg	Blocks sphingolipid biosynthesis	Apoptosis
Myriocin (ISP-1)	Small Molecules	N/A	SIH-233-25MG	25mg	Blocks sphingolipid biosynthesis	Apoptosis
N,N-Dimethylsphingosine	Small Molecules	N/A	SIH-235-5MG	5mg	Inhibits sphingosine kinase	Apoptosis
N,N-Dimethylsphingosine	Small Molecules	N/A	SIH-235-25MG	25mg	Inhibits sphingosine kinase	Apoptosis
Necrostatin	Small Molecules	N/A	SIH-213-10MG	10mg	Inhibits necroptosis	Apoptosis
Necrostatin	Small Molecules	N/A	SIH-213-50MG	50mg	Inhibits necroptosis	Apoptosis
Nigericin	Small Molecules	N/A	SIH-229-10MG	10mg	Induces rapid intracellular acidification	Apoptosis
Nigericin	Small Molecules	N/A	SIH-229-50MG	50mg	Induces rapid intracellular acidification	Apoptosis
NSC-66811	Small Molecules	N/A	SIH-338-10MG	10mg	p53/mdm2 inhibitor	Apoptosis
NSC-66811	Small Molecules	N/A	SIH-338-50MG	50mg	p53/mdm2 inhibitor	Apoptosis
NSC-687852 (b-AP15)	Small Molecules	N/A	SIH-339-5MG	5mg	DUB Inhibitor	Apoptosis
NSC-687852 (b-AP15)	Small Molecules	N/A	SIH-339-25MG	25mg	DUB Inhibitor	Apoptosis
Nutlin-3	Small Molecules	N/A	SIH-344-5MG	5mg	p53/mdm2 inhibitor	Apoptosis
Nutlin-3	Small Molecules	N/A	SIH-344-25MG	25mg	p53/mdm2 inhibitor	Apoptosis
Phenylbutyrate Na	Small Molecules	N/A	SIH-255-100MG	100mg	Histone deacetylase inhibitor	Apoptosis
Phenylbutyrate Na	Small Molecules	N/A	SIH-255-500MG	500mg	Histone deacetylase inhibitor	Apoptosis
PK-11195	Small Molecules	N/A	SIH-224-5MG	5mg	Mitochondrial benzodiazepine receptor ligand	Apoptosis
PK-11195	Small Molecules	N/A	SIH-224-25MG	25mg	Mitochondrial benzodiazepine receptor ligand	Apoptosis
PUMA (CT) Antibody	Antibodies	N/A	SPC-166C	25ug		Apoptosis
PUMA (CT) Antibody	Antibodies	N/A	SPC-166D	100ug		Apoptosis
PUMA (NT) Antibody	Antibodies	N/A	SPC-165C	25ug		Apoptosis
PUMA (NT) Antibody	Antibodies	N/A	SPC-165D	100ug		Apoptosis
Puromycin	Small Molecules	N/A	SIH-248-50MG	50mg	Translation inhibitor	Apoptosis
Puromycin	Small Molecules	N/A	SIH-248-250MG	250mg	Translation inhibitor	Apoptosis
PYR-41	Small Molecules	N/A	SIH-330-5MG	5mg	E1 UAE inhibitor	Apoptosis
PYR-41	Small Molecules	N/A	SIH-330-25MG	25mg	E1 UAE inhibitor	Apoptosis
R(-)-Gossypol	Small Molecules	N/A	SIH-223-10MG	10mg	Bcl-2 inhibitor	Apoptosis
R(-)-Gossypol	Small Molecules	N/A	SIH-223-50MG	50mg	Bcl-2 inhibitor	Apoptosis
Rapamycin	Small Molecules	N/A	SIH-212-5MG	5mg	mTOR inhibitor	Apoptosis
Rapamycin	Small Molecules	N/A	SIH-212-25MG	25mg	mTOR inhibitor	Apoptosis
Resveratrol	Small Molecules	N/A	SIH-264-100MG	100mg	Antioxidant	Apoptosis
Resveratrol	Small Molecules	N/A	SIH-264-500MG	500mg	Antioxidant	Apoptosis
Retinoic acid	Small Molecules	N/A	SIH-258-50MG	50mg	Retinoid RAR agonist	Apoptosis
Retinoic acid	Small Molecules	N/A	SIH-258-250MG	250mg	Retinoid RAR agonist	Apoptosis
Simvastatin	Small Molecules	N/A	SIH-257-50MG	50mg	HMG-CoA reductase inhibitor	Apoptosis
Simvastatin	Small Molecules	N/A	SIH-257-250MG	250mg	HMG-CoA reductase inhibitor	Apoptosis
SL-01	Small Molecules	N/A	SIH-343-50MG	50mg	p53/mdm2 inhibitor	Apoptosis
SMER3	Small Molecules	N/A	SIH-341-10MG	10mg	E3 UB ligase inhibitor	Apoptosis
SMER3	Small Molecules	N/A	SIH-341-50MG	50mg	E3 UB ligase inhibitor	Apoptosis
Sphingosine	Small Molecules	N/A	SIH-202-25MG	25mg	Protein Kinase C inhibitor	Apoptosis
Sphingosine	Small Molecules	N/A	SIH-202-100MG	100mg	Protein Kinase C inhibitor	Apoptosis
Staurosporine	Small Molecules	N/A	SIH-253-250UG	250ug	Protein kinase inhibitor	Apoptosis
Staurosporine	Small Molecules	N/A	SIH-253-1MG	1mg	Protein kinase inhibitor	Apoptosis
Sulindac Sulfide	Small Molecules	N/A	SIH-261-10MG	10mg	NFkB inhibitor	Apoptosis
Sulindac Sulfide	Small Molecules	N/A	SIH-261-50MG	50mg	NFkB inhibitor	Apoptosis
Sulindac Sulfone	Small Molecules	N/A	SIH-262-10MG	10mg	Modulates beta-catenin-mediated effects	Apoptosis
Sulindac Sulfone	Small Molecules	N/A	SIH-262-50MG	50mg	Modulates beta-catenin-mediated effects	Apoptosis
Taxol	Small Molecules	N/A	SIH-239-10MG	10mg	Microtubule stabilizing agent	Apoptosis
Taxol	Small Molecules	N/A	SIH-239-50MG	50mg	Microtubule stabilizing agent	Apoptosis
TCID	Small Molecules	N/A	SIH-340-10MG	10mg	DUB Inhibitor	Apoptosis
TCID	Small Molecules	N/A	SIH-340-50MG	50mg	DUB Inhibitor	Apoptosis
Thalidomide	Small Molecules	N/A	SIH-336-100MG	100mg	E3 UB ligase inhibitor	Apoptosis
Thalidomide	Small Molecules	N/A	SIH-336-500MG	500mg	E3 UB ligase inhibitor	Apoptosis
TPCK	Small Molecules	N/A	SIH-207-500MG	500mg	Serine protease inhibitor	Apoptosis
TPEN	Small Molecules	N/A	SIH-231-100MG	100mg	Intracellular Zn2+ chelator	Apoptosis
TPEN	Small Molecules	N/A	SIH-231-500MG	500mg	Intracellular Zn2+ chelator	Apoptosis
Triacsin C	Small Molecules	N/A	SIH-203-100UG	100ug	Fatty acyl-CoA synthase inhibitor	Apoptosis
Triacsin C	Small Molecules	N/A	SIH-203-1MG	1mg	Fatty acyl-CoA synthase inhibitor	Apoptosis
Trichostatin A	Small Molecules	N/A	SIH-254-1MG	1mg	Histone deacetylase inhibitor	Apoptosis
Trichostatin A	Small Molecules	N/A	SIH-254-5MG	5mg	Histone deacetylase inhibitor	Apoptosis
Troglitazone	Small Molecules	N/A	SIH-260-10MG	10mg	PPARgamma agonist	Apoptosis
Troglitazone	Small Molecules	N/A	SIH-260-50MG	50mg	PPARgamma agonist	Apoptosis
TSP23 Antibody	Antibodies	Tsp232A	SMC-194D	100ug		Apoptosis, Chaperones, Heat Shock
U-74389G	Small Molecules	N/A	SIH-205-100MG	100mg	Free radical scavenger	Apoptosis
U-74389G	Small Molecules	N/A	SIH-205-500MG	500mg	Free radical scavenger	Apoptosis
Ubiquitin Antibody	Antibodies	5B9-B3	SMC-160A	50ug		Apoptosis, Cell Signaling
Ubiquitin Antibody	Antibodies	6C11-B3	SMC-171A	50ug		Apoptosis, Cell Signaling
Ubiquitin Antibody	Antibodies	6C11-B3	SMC-171B	200ug		Apoptosis, Cell Signaling
Ubiquitin Antibody	Antibodies	N/A	SPC-119A	50ug		Apoptosis, Cell Signaling
Ubiquitin Antibody	Antibodies	N/A	SPC-119B	200ug		Apoptosis, Cell Signaling
Valinomycin	Small Molecules	N/A	SIH-230-10MG	10mg	Induces loss of mitochondrial membrane potential	Apoptosis
Valinomycin	Small Molecules	N/A	SIH-230-50MG	50mg	Induces loss of mitochondrial membrane potential	Apoptosis
WP-1130	Small Molecules	N/A	SIH-337-5MG	5mg	DUB Inhibitor	Apoptosis
WP-1130	Small Molecules	N/A	SIH-337-25MG	25mg	DUB Inhibitor	Apoptosis
Z-Asp-CH2-DCB	Small Molecules	N/A	SIH-206-10MG	10mg	Caspase inhibitor	Apoptosis
Z-Asp-CH2-DCB	Small Molecules	N/A	SIH-206-50MG	50mg	Caspase inhibitor	Apoptosis
Zerumbone	Small Molecules	N/A	SIH-265-10MG	10mg	Enhances apoptotic effect of TRAIL	Apoptosis
Zerumbone	Small Molecules	N/A	SIH-265-50MG	50mg	Enhances apoptotic effect of TRAIL	Apoptosis