full screen background image

                        

Polymyxin B6 sulfate, EvoPure®

Description

Polymyxin B sulfate is a polypeptide antibiotic and is composed of polymyxins B1, B2, and B3 with fractions B1 and B2 comprising the majority of the mixture. Polymyxin B6 sulfate is freely soluble in aqueous solution (25 mg/mL). Polymyxin B components are structurally identical with the exception of a variable fatty acid group on each fraction. Results from in vitrostudies have shown marginal differences in MIC data when comparing the fractions.We offer six forms of polymyxin B sulfate: polymyxin B sulfate (P007), polymyxin B1 sulfate, EvoPure® (P037), polymyxin B1-I sulfate, EvoPure® (P038), polymyxin B2 sulfate, EvoPure® (P039), polymyxin B3 sulfate, EvoPure® (P040), and polymyxin B6 sulfate, EvoPure®. EvoPure® products are purified single antibiotic fractions, most >99% pure. High purity EvoPure® polymyxin products can be used to analyze the specifc effects of individual polymyxin B fractions.Mechanism:Polymyxin B targets and alters permeability lipopolysaccharide (LPS) of gram negative bacteria leading to lysing of the cell. Polymyxin B only needs to interact with LPS, it is not required to enter the cell.Spectrum:Polymyxin B sulfate targets the outer membrane of gram negative bacteria especially Pseudomonas aeruginosa.Microbiology Applications:Polymyxin B sulfate is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

Price: EUR 1074.08