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Bleomycin A2 sulfate, EvoPure®

Description

Bleomycin A2 sulfate is one of two components found in the glycopeptide antibiotic bleomycin sulfate, a chemotherapeutic agent used for the treatment of Hodgkin's lymphoma. Bleomycin A2 and B2 are structurally similar and differ by a unique terminal amine group.

We offer three forms of bleomycin: bleomycin sulfate (B005), bleomycin A2 sulfate, EvoPure® (B019), and bleomycin B2 sulfate, EvoPure® (B020). EvoPure® products are individual molecular fractions, most >99% pure.

Mechanism:
Bleomycin acts as an anticancer agent by causing single stranded breaks in DNA. The exact mechanism is not well defined however; it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which create single stranded breaks in deoxyribose sugar.

Cancer Applications:
Bleomycin binds to specific DNA sequences and causing single-stranded and double-stranded DNA breaks, causing cell death. As a result Bleomycin can be used as gene selection agent. Only plantlets possessing a newly introduced resistance gene (Ble) in combination with a random gene of interest will be able to survive a bleomycin application as is shown in tobacco by Miki and co-workers (2003).

Form:
Powder

Purity Level:
≥99.0%

Price: (EUR)

Packaging: Regular Price: Promo Price:
1 x 5 mg 1074.08 377.00