As anti-tumor therapy or antimicrobial diseases or conditions such drug resistance is a decrease in the efficiency of the drug. If it is not intended for the drug to inhibit or kill the pathogen, the subsequent period is equal to the drug resistance dose or disorder. In many cases, that the term "has acquired" pathogenic resistance that is used in the context of the resistors are the same. I is said organisms, and are multi-resistant when there is resistant to multiple drugs. It is a system for drug delivery in a wider sense of the body's immune system, but are faced with the same problems as competitive drug delivery independent external.         Development of resistance to antibiotics, in particular, derived from a targeted drug bacterial specific proteins. Drug because it is specified that mutation of any of these proteins, or reject preventing destructive effect as a result of antibiotic resistance. By not only be able to not only bacteria, and is aimed at modification antibiotics enzymes and enzymes are used to change the antibiotic itself, therefore, to neutralize it. Examples of macrolide-resistant Streptococcus pathogen Staphylococcus aureus to be changed, and vancomycin-resistant enterococci, and examples of aminoglycoside resistance Acinetobacter baumannii and antibiotic modified microorganism Pseudomonas aeruginosa.         In general, along with the innate ability of microorganisms to develop resistance at a rate that exceeds the development of new drugs, and the executable, lack of coordination efforts, the development of antibiotic long-term treatment in the pharmaceutical industry and government After showing the existing strategies for, account is doomed to failure. If there is no alternative strategy, trying to be one of the threat of the most important public health humanity in the 21st century are facing, the acquisition of drug resistance pathogens loom. The chemical resistance, one aspect of the problem, for example, the resistance of the other creatures to physical factors such as a magnetic temperature, pressure, sound, and radiation, are not covered in this article, physical affecting the microbial life It is included in the factors.
        It is a result in response to the pressure chemical resistance toxins or imposed on any biological or evolving drugs. Sensitivity to the drug used is different, some individual organisms, may be able to survive the drug treatment in the fitness and more. As a consequence of the population is more resistant, resistant traits are passed on to offspring subsequent to each drug. The drugs used, unless it impossible to horizontal gene transfer or cell division or sexual reproduction in the target population of all, drug resistance, follow inevitably. This is some cells can be seen in cancerous tumors, which can develop resistance to drugs used in chemotherapy. Chemotherapy, causing near fibroblasts tumor mass production of protein WNT16B. This protein stimulates the proliferation of cancer cells that are resistant. Malaria is a threat of revival in sub-Saharan Africa and Southeast Asia in 2012, a huge problem, resistant strains of Plasmodium falciparum is the health authorities. The leprosy, improving the resistance to dapsone is shown.         Direct transcription of a specific gene in biofilm state is present, exists between the single-cell organisms, rapid exchange process of the resistor is referred to as horizontal gene transfer. Such a method, are asexual by fungi called "sexual perversion". Examples of resistant strains, and bacteria, viruses, and parasites, - you can be found in micro-organisms and ecto, plants, fungi, arthropods, mammals, birds, reptiles, fish, and amphibians. In the domestic environment, the use of a detergent use of bleaching agents such as this, mouthwash and toothbrush, antibiotics, and disinfectants, shampoo, soap, drug-resistant strains of organisms, seemingly safe antibacterial soap, such as hand-washing, especially deodorant that may arise from the activity, sunscreen, cosmetics and all of it is a spray application surface of the ups and downs medical products, and pesticides.
        There are the chemical substances contained in these products , to target organisms have the potential to harm beneficial organisms to develop resistance inadvertently or intentionally. "Development, and supply of drugs, careless practices in use it is to accelerate it unnecessarily naturally drug resistance." - Global Development Center "Excessive use of antibacterial cleaners in the home, so that it is possible to produce a strain of multi-drug resistant bacteria." - Australian Government - health channel better Has led to a relentless increase in the number and type of bacterial resistance to drugs of misuse these with the use of antimicrobials in animal husbandry and human medicine in 70 years "past - the death, the medical high disabilities and suffering, and more . World Health Organization 2010 - "as increased costs That the pathogen most. Resistance first-line drug death from tuberculosis account and malaria, to cause these diseases for more than 85% of death "acute respiratory infections, diarrhea, measles, AIDS, due to infectious diseases worldwide is, in the case of 100% or. several thirdline agent - and the second, which will be different each time almost from scratch, resistance to compromise the results of the treatment seriously, important global burden of nosocomial infection of resistance, virus resistance further poor and disease. alienation of the population growth problem of drug resistance in the parasite ignored the issue of the emergence of reproduction."
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