Assay Kits, Recombinant Proteins & Biochemicals

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Assay Kits

Product

Catalog No.

Size

Price (EURO)

Description

Acetate Colorimetric Assay Kit

K658-100

100 assays

472.5

In Biovision's Acetate Assay Kit, Acetate is converted to an intermediate in the presence of Acetate Enzyme Mix & Acetate Substrate Mix. The intermediate reduces a colorless probe to a colored product with strong absorbance at 450 nm. The Acetate Colorimetric Assay Kit is rapid, simple & sensitive. It can detect less than 20 µM Acetate in various samples.

ADP Colorimetric Assay Kit II

K356-100

100 assays

498.5

BioVision ADP Assay kit II is suitable for measuring ADP levels in samples that contain reducing substances, which may interfere with oxidase-based assays. In this assay, ADP in the presence of ADP Enzyme Mix is converted to an intermediate, which reduces a colorless Probe to a colored product with strong absorbance at 450 nm. ADP Assay Kit II is simple, fast and high-throughput ready. It can detect less than 20 μM of ADP in samples.

Progranulin (human) ELISA Kit

K4738-100

100 assays

953.5

BioVision's Progranulin (human) ELISA kit is a sandwich Enzyme Linked-Immunosorbent Assay (ELISA) for quantitative determination of human progranulin in biological fluids.

Progranulin (mouse) ELISA Kit

K4734-100

100 assays

953.5

BioVision's Progranulin (mouse) ELISA kit is a sandwich Enzyme Linked-Immunosorbent Assay (ELISA) for quantitative determination of human progranulin in biological fluids.

Progranulin (rat) ELISA Kit

K4735-100

100 assays

953.5

BioVision's Progranulin (rat) ELISA kit is a sandwich Enzyme Linked-Immunosorbent Assay (ELISA) for quantitative determination of human progranulin in biological fluids.

 

 

Recombinant Proteins

Product

Catalog No.

Size

Price (EURO)

Description

Heat Shock Protein 27, human recombinant (New Sizes)

4853-50
4853-1000

50 μg
1 mg

953.5

5185

Recombinant Human Heat Shock Protein produced in E.Coli is a single, non-glycosylated polypeptide chain containing 205 amino acids and have a molecular weight of 22.7 kDa. The protein was purified by proprietary chromatographic techniques.

PIN1, human recombinant

6304-100

100 μg

407.5

Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity.

PP2C alpha, human recombinant

6303-100

100 μg

355.5

Protein phosphatase 2C (PP2C alpha) is a Mn2+- or Mg2+- dependent protein serine/threonine phosphatase that is essential for regulating cellular stress response in eukaryotes. The protein coding region of PP2C alpha (amino acids 1-382) was cloned into an E. coli expression vector. PP2C alpha was overexpressed in E. coli as a soluble His-tag fusion protein.

PTP1B, human reocmbinant

6301-100

100 μg

355.5

The protein coding region of the catalytic domain of PTP-1B (amino acids 1-321) was cloned into an E. coli expression vector. The catalytic domain of PTP-1B was overexpressed in E. coli as a soluble protein. Useful for the study of tyrosine phosphatase kinetics, substrate specificity and for screening inhibitors.

Renin, human recombinant

6307-10
6307-50
6307-100

10 μg
50 μg
100 μg

173.5

537.5

882

BioVision's human renin is produced from the proenzyme prorenin by proteolytic cleavage of a 43 amino acid N-terminal prosegment using limited enzymatic digestion by immobilized trypsin and purified by affinity chromatography. Conversion to active renin is >99.99 percent.

SHP-1, human reombinant

6302-100

100 μg

563.5

The protein coding region of the catalytic domain of SHP-1 (amino acids 243-541) was cloned into an E. coli expression vector. The catalytic domain of SHP-1 was overexpressed as insoluble protein aggregates (inclusion bodies). SHP-1 is a well-known inhibitor of activation-promoting signaling cascades in hematopoietic cells.

Thiordoxin, human recombinant

6305-100

100 μg

355.5

Thioredoxin (Trx) is a low molecular weight redox protein. Trx contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. It is involved in the first unique step in DNA synthesis. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation

UCHL1, human recombinant

6306-100

100 μg

407.5

UCH-L1/PGP9.5 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Recombinant UCHL1 protein was expressed in E.coli.

 

 

 

Biochemicals

Product

Catalog No.

Size

Price (EURO)

Description

Acyclovir

2200-50
2200-250

50 mg
250 mg

134.5

381.5

Acyclovir is an antiviral agent with activity against herpesvirus types 1 and 2 and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate) that inhibits the synthesis of deoxyribonucleic acid (DNA) molecules in the virally infected cells, thereby inhibiting viral replication.

Aminopurvalanol A

2205-1
2205-5

1 mg
5 mg

121.5

336

A cell-permeable, reversible and competitive inhibitor of cyclin-dependent kinases. IC50 values are: CDK1/cyclin B (33 nM), CDK2/cyclin A (33 nM), CDK2/cyclin E (28 nM) and CDK5/p35 (20 nM).

Cathepsin G Substrate, Colorimetric

2206-5
2206-25

5 mg
25 mg

121.5

336

An excellent colorimetric substrate for cathepsin G.

Compound W

2208-50
2208-250

50 mg
250 mg

121.5

336

Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.

Diprotin A

2191-5
2191-25

5 mg
25 mg

121.5

277.5

A dipeptidyl aminopeptidase IV (DPP IV) inhibitor. Enhances recruitment of CXCR4 positive circulating endothelial progenitors to myocardium.

Diprotin B

2192-5
2192-25

5 mg
25 mg

121.5

277.5

An inhibitor of dipeptidyl aminopeptidase IV (DPP IV).

Epoxomicin

2190-50
2190-250

50 µg
250 µg

167

563.5

Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin (Cat. No. 1709-100). Blocks also trypsin-like and PGPH activities of the proteasome.

DiscoveryPak™ HDAC Inhibitor Set II

K876-7

7 inhibitors

771.5

A convenient set of seven individual HDAC (Histone Deacetylase) inhibitors.

HDAC Substrate, Colorimetric

2207-25
2207-100

25 mg
100 mg

134.5

336

A colorimetric substrate for histone deacetylases (HDACs).

IDE-1

2193-1
2193-5

1 mg
5 mg

160.5

472.5

Cell-permeable. Directs differentiation of embryonic stem cells (ESCs) into the endodermal lineage (EC50 = 125 nM). Nodal/Smad signaling is activated indicating IDE-1 functions via TGF-β-signaling pathway.

(-)-Indolactam V

2197-250
2197-1000

250 µg
1 mg

186.5

453

Cell-permeable. A protein kinase C (PKC) activator and a tumor promoter. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.

MDL 28170

2195-10
2195-50

10 mg
50 mg

152.7

433.5

A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of formation by inhibiting the formation of intermediate Aβ46 and protecting from degradation.

PFI-1

2203-1
2203-5

1 mg
5 mg

121.5

303.5

PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC50 values of 98 nM and 0.22 μM, respectively.

Pyroxamide

2189-5
2189-25

5 mg
25 mg

138.4

433.5

Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) (IC50 = 100 nM). It induces growth suppression and cell death of certain types of cancer cells in culture.

Ribavirin

2199-10
2199-50

10 mg
50 mg

121.5

336

Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5'-phosphate, affects virus-infected cells primarily by inhibiting the enzyme inosine 5'-monophosphate (IMP) dehydrogenase. It potently suppresses eIF4E-mediated oncogenic transformation of murine cells in vitro, of tumor growth of a mouse model of eIF4E-dependent human squamous cell carcinoma in vivo, and of colony formation of eIF4E-dependent acute myelogenous leukemia cells derived from human patients.

SAG Analog (cis-isomer)

2194-500
2194-1000

500 µg
1 mg

251.5

407.5

A cell-permeable, highly active, Sonic hedgehog (Shh) signaling agonist. Smoothened (Smo) agonist.

SAG Analog (trans-isomer)

2196-500
2196-1000

500 µg
1 mg

251.5

407.5

A cell-permeable, low toxicity, Sonic hedgehog (Shh) signaling agonist. Smoothened (Smo) agonist. Also acts as a potent activator of VEGF expression in vitro.

SBHA

2202-50
2202-250

50 mg
250 mg

121.5

303.5

SBHA is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. SBHA also enhances cytotoxicity induced by Oxaliplatin in the colorectal cancer cell lines.

TCID

2204-5
2204-25

5 mg
25 mg

134.5

381.5

Cell-permeable. A potent and selective inhibitor of ubiquitin C-terminal hydrolase L3 (UCH-L3) (IC50 = 0.6 µM). Inhibits ubiquitin C-terminal hydrolase L1 (UCH-L1) only at higher concentrations (IC50 = 75 µM).

Valacyclovir Hydrochloride Hydrate

2201-10
2201-50

10 mg
50 mg

134.5

381.5

Valacyclovir is a prodrug of Acyclovir (Cat.No. 2200-50, 250) with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competitive inhibition of viral DNA polymerase, and by incorporation into and termination of the growing viral DNA chain.

Vildagliptin

2188-10
2188-50

10 mg
50 mg

238.5

680.5

An antidiabetic agent. A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that breaks down Glucagon-like peptide 1 (GLP-1). By delaying the degradation of GLP-1, vildagliptin extends the action of insulin while also suppressing the release of glucagon. This leads to a reduction in elevated blood glucose levels (hyperglycemia), which is a characteristic feature of type 2 diabetes.

WST-1

2198-10
2198-30

10 mg
30 mg

134.5

264.5

A water-soluble tetrazolium reagent that serves as a sensitive chromogenic indicator for NADH. It is reduced by NADH at neutral pHs in the presence of 1-methoxy PMS to produce the corresponding formazan dye that absorbs at 438 nM. Useful in cell proliferation assays as a cell viability indicator.