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High throughput glycan & glycopeptide identification tool for data from TripleTOF, MALDI TOF/TOF, LC-MS/MS systems

SimGlycan® predicts the structure of glycans and glycopeptides from the MS/MS data acquired by mass spectrometry. Comprehensive support for resolving glycopeptides obtained from an LC-MS/MS run facilitating glycosylation studies. SimGlycan® accepts experimental MS profiles, matches them with its own database to generate a list of candidate structures based on a robust scoring mechanism. SimGlycan® also supports multi stage mass spectrometry (MS data analysis.
Robust Glycan& Glycopeptide Database
The SimGlycan® database is a large relational database containing 22,456 glycans, 22,814 glycoproteins, 11,438 glycans with known biological sources, 11,918 glycans with known classes, 263 biochemical reactions, 194 biochemical pathways. The database is continuously updated as information on additional glycans and glycopeptides is published.
Generate Annotated Spectrum
SimGlycan® highlights the experimental m/z values that match those of theoretical fragments and generates an annotated spectrum. Each peak can be represented using cartoons or Domon Costello nomenclature. It enables generating annotated spectra either to fit on a page or based on area of interest and export plots as image files to MS PowerPoint for sharing the findings with your colleagues.

User Drawn Structures
SimGlycan® enables users to draw and edit glycans and glycopeptides. A monosaccharide, peptide chain or a substituent such as N-SO3, EtN can be added or deleted and branching points and anomeric linkages can be modified at the click of a button. At each step, the fragmentation of the drawn structure enables a user to compare the experimental and theoretical data, enabling the user to see whether the modification brings theoretical glycan closer to the experimental data. This feature greatly assists in resolving glycan structures.
Accurate Ranking
All possible glycan/glycopeptide structures are ranked and scored based on our proprietary search and score mechanism. The ranking mechanism is based on calculating the proximity score, which is a numerical representation of how closely the experimental properties (composition and branching pattern) of the glycan match with those of glycans in database.

To activate & evaluate, follow these steps
- Install SimGlycan ® from the website or the CD
- Launch and click Evaluate on the first window that opens
- Enter the evaluation key requested from us

Cat.Number: SG1

PRICE: $7 885,00