full screen background image

                        

Polymyxin B3 sulfate, EvoPure®

Description

Polymyxin B3 sulfate is an individual fraction found in the antibiotic mixture polymyxin B sulfate. Polymyxin B3 sulfate is differentiated from its counterpart fractions by the presence of a 3-hydroxy-6-methyloctanoic acid (3-OH-6-MOA) fatty acid moiety. Results from in vitro studies have shown marginal differences in MIC data when comparing the fractions.We offer six forms of polymyxin B sulfate: polymyxin B sulfate (P007), polymyxin B1 sulfate, EvoPure® (P037), polymyxin B1-I sulfate, EvoPure® (P038), polymyxin B2 sulfate, EvoPure® (P039), polymyxin B3 sulfate, EvoPure® (P040), and polymyxin B6 sulfate, EvoPure®. EvoPure® products are purified single antibiotic fractions, most >99% pure. High purity EvoPure® polymyxin products can be used to analyze the specifc effects of individual polymyxin B fractions.Mechanism:Polymyxin B targets and alters permeability lipopolysaccharide (LPS) of gram negative bacteria leading to lysing of the cell. Polymyxin B only needs to interact with LPS, it is not required to enter the cell.Spectrum:Polymyxin B sulfate targets the outer membrane of gram negative bacteria especially Pseudomonas aeruginosa.Microbiology Applications:Polymyxin B sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Pseudomonas aeruginosa 0.25 µg/mL – 1 µg/mLFor a complete list of polymyxin B sulfate MIC values, click here.Plant Biology ApplicationsPolymyxin B sulfate was successfully tested to counteract phytopathogenic gram-negative bacterial growth including different strains of Pseudomonas viridiflava and Erwinia carotovora. Polymixin B sulfate was shown to reduce bacterial growth of different strains of Pseudomonas viridiflava at low concentrations, (0.08 µg/ml) and Erwinia carotovora growth at slightly higher concentrations (0.25 µg/ml) (Selim et al. 2005).Form:PowderPurity Level:>90.0%

Price: EUR 1074.78